Sulfur Hexafluoride
Sulfur hexafluoride is a chemically inert, non-toxic gas used as an ultrasound contrast agent (SonoVue/Lumason) encapsulated in phospholipid microbubbles to enhance echocardiographic imaging of cardiac structures and vascularity of focal liver lesions and other organs. The microbubbles oscillate resonantly under ultrasound insonation, dramatically increasing acoustic backscatter from blood pool to improve contrast between vasculature and surrounding tissue. It is also used in ophthalmology as a vitreous tamponade for retinal detachment repair.
Molecular Weight
146.0600 g/mol
LogP
4.20
TPSA
1.00 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Enhances the contrast of specific tissues or structures during medical imaging procedures by altering the local signal intensity or X-ray absorption characteristics.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the contrast of specific tissues or structures during medical imaging procedures by altering the local signal intensity or X-ray absorption characteristics.
2D Structure
Cite this structure
Embed this structure
SMILES
FS(F)(F)(F)(F)F
InChI
InChI=1S/F6S/c1-7(2,3,4,5)6
Molecular Formula
F6S
HBD / HBA
- / 6
Rotatable Bonds
0
Heavy Atoms
7
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Sulfur hexafluoride is a chemically inert, non-toxic gas used as an ultrasound contrast agent (SonoVue/Lumason) encapsulated in phospholipid microbubbles to enhance echocardiographic imaging of cardiac structures and vascularity of focal liver lesions and other organs. The microbubbles oscillate resonantly under ultrasound insonation, dramatically increasing acoustic backscatter from blood pool to improve contrast between vasculature and surrounding tissue. It is also used in ophthalmology as a vitreous tamponade for retinal detachment repair.
Enhances the contrast of specific tissues or structures during medical imaging procedures by altering the local signal intensity or X-ray absorption characteristics.
Yes, Sulfur Hexafluoride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1796998. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 17358. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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