Taliglucerase Alfa
Taliglucerase alfa is a recombinant form of the enzyme glucocerebrosidase, produced in plant cell culture, used as enzyme replacement therapy for Gaucher disease type 1. It works by breaking down accumulated glucocerebroside in macrophages, reducing organomegaly, cytopenias, and bone complications. It represents the first plant-cell-derived recombinant therapeutic protein approved for human use.
Mechanism of Action
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Taliglucerase alfa is a recombinant form of the enzyme glucocerebrosidase, produced in plant cell culture, used as enzyme replacement therapy for Gaucher disease type 1. It works by breaking down accumulated glucocerebroside in macrophages, reducing organomegaly, cytopenias, and bone complications. It represents the first plant-cell-derived recombinant therapeutic protein approved for human use.
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Yes, Taliglucerase Alfa is an approved drug. It has reached clinical phase 4. It is classified as a Enzyme.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1964120. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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