Tapentadol

CHEMBL1201776 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

221.3 g/mol

LogP

3.5

Phase

4

This is a prescription opioid pain reliever used to manage moderate to severe pain, including long-term (chronic) pain in adults. It works both by binding to opioid receptors and by blocking the reuptake of norepinephrine, a brain chemical involved in pain signaling. Like all opioids, it carries a risk of dependence and should be used only as directed by a doctor.

Molecular Weight

221.3400 g/mol

LogP

3.50

TPSA

23.50 Å²

Lipinski RO5

Pass

Therapeutic Areas

Bladder Cancer Breast Cancer Chronic Pain Colorectal Cancer Non-Small Cell Lung Cancer Ovarian Cancer Pain Management Pancreatic Cancer Prostate Cancer Rheumatoid Arthritis Thyroid Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

CC[C@@H](c1cccc(O)c1)[C@@H](C)CN(C)C

InChI

InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1

Molecular Formula

C14H23NO

HBD / HBA

1 / 2

Rotatable Bonds

5

Heavy Atoms

16

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

This is a prescription opioid pain reliever used to manage moderate to severe pain, including long-term (chronic) pain in adults. It works both by binding to opioid receptors and by blocking the reuptake of norepinephrine, a brain chemical involved in pain signaling. Like all opioids, it carries a risk of dependence and should be used only as directed by a doctor.

Yes, Tapentadol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

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References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201776. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 9838022. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C14H23NO
Synonyms: 2

External Links

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.