Tecovirimat
Tecovirimat is an antiviral agent that inhibits the VP37 protein of orthopoxviruses, blocking the wrapping of intracellular mature virions and thereby preventing efficient spread of the virus between cells and to extracellular environments. It is approved for the treatment of smallpox and has been used under emergency authorization for mpox (monkeypox), representing a key countermeasure in orthopoxvirus preparedness. Its highly selective mechanism targets a viral protein with no human homolog, providing a favorable safety profile.
Molecular Weight
376.3000 g/mol
LogP
2.60
TPSA
66.50 Ų
Lipinski RO5
Pass
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
O=C(NN1C(=O)[C@@H]2[C@@H]3C=C[C@@H]([C@H]4C[C@@H]34)[C@@H]2C1=O)c1ccc(C(F)(F)F)cc1
InChI
InChI=1S/C19H15F3N2O3/c20-19(21,22)9-3-1-8(2-4-9)16(25)23-24-17(26)14-10-5-6-11(13-7-12(10)13)15(14)18(24)27/h1-6,10-15H,7H2,(H,23,25)/t10-,11+,12+,13-,14-,15+
Molecular Formula
C19H15F3N2O3
HBD / HBA
1 / 6
Rotatable Bonds
1
Heavy Atoms
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Tecovirimat is an antiviral agent that inhibits the VP37 protein of orthopoxviruses, blocking the wrapping of intracellular mature virions and thereby preventing efficient spread of the virus between cells and to extracellular environments. It is approved for the treatment of smallpox and has been used under emergency authorization for mpox (monkeypox), representing a key countermeasure in orthopoxvirus preparedness. Its highly selective mechanism targets a viral protein with no human homolog, providing a favorable safety profile.
Yes, Tecovirimat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1257073. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 16124688. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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