Temafloxacin Hydrochloride
Temafloxacin hydrochloride is the hydrochloride salt form of temafloxacin, a fluoroquinolone antibiotic withdrawn from the market due to severe idiosyncratic adverse effects including hemolytic anemia. See temafloxacin for complete pharmacological details. This salt form was used in oral formulations prior to market withdrawal.
Molecular Weight
453.8000 g/mol
TPSA
72.90 Ų
Mechanism of Action
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
2D Structure
Cite this structure
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SMILES
CC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)CCN1.Cl
InChI
InChI=1S/C21H18F3N3O3.ClH/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23;/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30);1H
Molecular Formula
C21H19ClF3N3O3
HBD / HBA
3 / 9
Rotatable Bonds
3
Heavy Atoms
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Temafloxacin hydrochloride is the hydrochloride salt form of temafloxacin, a fluoroquinolone antibiotic withdrawn from the market due to severe idiosyncratic adverse effects including hemolytic anemia. See temafloxacin for complete pharmacological details. This salt form was used in oral formulations prior to market withdrawal.
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.
Yes, Temafloxacin Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2107495. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60020. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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