Thiothixene Hydrochloride
Thiothixene hydrochloride is the hydrochloride salt form of thiothixene, a thioxanthene antipsychotic dopamine D2 receptor antagonist. See thiothixene for complete pharmacological details. This salt formulation provides improved water solubility for oral liquid and injectable preparations used in schizophrenia, bipolar disorder, and obesity-related psychiatric management.
Molecular Weight
480.1000 g/mol
TPSA
77.50 Ų
Therapeutic Areas
Mechanism of Action
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
2D Structure
Cite this structure
Embed this structure
SMILES
CN1CCN(CC/C=C2/c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1.Cl.Cl.O.O
InChI
InChI=1S/C23H29N3O2S2.2ClH.2H2O/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26;;;;/h4-5,7-11,17H,6,12-16H2,1-3H3;2*1H;2*1H2/b19-8-;;;;
Molecular Formula
C23H30ClN3O2S2
HBD / HBA
1 / 6
Rotatable Bonds
5
Heavy Atoms
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Thiothixene hydrochloride is the hydrochloride salt form of thiothixene, a thioxanthene antipsychotic dopamine D2 receptor antagonist. See thiothixene for complete pharmacological details. This salt formulation provides improved water solubility for oral liquid and injectable preparations used in schizophrenia, bipolar disorder, and obesity-related psychiatric management.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Thiothixene Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989824. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11957704. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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