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Tiagabine

CHEMBL1027 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
375.6 g/mol
LogP
2.7
Phase
4

This anticonvulsant medication is used as an add-on treatment for partial seizures in adults and children over the age of twelve. It works by blocking the reuptake of GABA, an inhibitory brain chemical, thereby reducing abnormal electrical activity in the brain. Seizures can paradoxically worsen in some patients who do not have epilepsy, so it is only recommended for this condition.

Molecular Weight

375.6000 g/mol

LogP

2.70

TPSA

97.00 Ų

Lipinski RO5

Pass

Therapeutic Areas

Epilepsy Generalized Anxiety Disorder Schizophrenia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1ccsc1C(=CCCN1CCC[C@@H](C(=O)O)C1)c1sccc1C

                

                

                
                

                    
InChI

                    
InChI=1S/C20H25NO2S2/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23)/t16-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C20H25NO2S2

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
Rotatable Bonds

                        
6

                    

                    
                    
                    

                        
Heavy Atoms

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
This anticonvulsant medication is used as an add-on treatment for partial seizures in adults and children over the age of twelve. It works by blocking the reuptake of GABA, an inhibitory brain chemical, thereby reducing abnormal electrical activity in the brain. Seizures can paradoxically worsen in some patients who do not have epilepsy, so it is only recommended for this condition.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Tiagabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1027.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60648.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.