Tivozanib
This targeted therapy is used to treat adults with relapsed or refractory advanced renal cell carcinoma (kidney cancer) after two or more prior treatments. It works by blocking VEGF receptors, which cuts off the blood supply that tumors need to grow and spread. It is taken as an oral capsule on a schedule of three weeks on and one week off.
Molecular Weight
454.9000 g/mol
LogP
4.00
TPSA
108.00 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
2D Structure
Cite this structure
Embed this structure
SMILES
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
InChI
InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
Molecular Formula
C22H19ClN4O5
HBD / HBA
2 / 7
Rotatable Bonds
6
Heavy Atoms
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
This targeted therapy is used to treat adults with relapsed or refractory advanced renal cell carcinoma (kidney cancer) after two or more prior treatments. It works by blocking VEGF receptors, which cuts off the blood supply that tumors need to grow and spread. It is taken as an oral capsule on a schedule of three weeks on and one week off.
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
Yes, Tivozanib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1289494. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9911830. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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