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Triclabendazole

CHEMBL1086440 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
359.7 g/mol
LogP
5.7
Phase
4

Triclabendazole is a benzimidazole anthelmintic specifically active against immature and adult liver flukes (Fasciola hepatica and F. gigantica) that inhibits tubulin polymerization in flukes, disrupting cellular structure and motility, and may also affect energy metabolism. It is approved by the WHO for treatment of fascioliasis and is also active against Clonorchis and Opisthorchis species. Its efficacy against both immature and adult liver flukes distinguishes it from other anthelmintics and makes it the drug of choice for fascioliasis.

Molecular Weight

359.7000 g/mol

LogP

5.70

TPSA

63.20 Ų

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CSc1nc2cc(Cl)c(Oc3cccc(Cl)c3Cl)cc2[nH]1

                

                

                
                

                    
InChI

                    
InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H9Cl3N2OS

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
Rotatable Bonds

                        
3

                    

                    
                    
                    

                        
Heavy Atoms

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Triclabendazole is a benzimidazole anthelmintic specifically active against immature and adult liver flukes (Fasciola hepatica and F. gigantica) that inhibits tubulin polymerization in flukes, disrupting cellular structure and motility, and may also affect energy metabolism. It is approved by the WHO for treatment of fascioliasis and is also active against Clonorchis and Opisthorchis species. Its efficacy against both immature and adult liver flukes distinguishes it from other anthelmintics and makes it the drug of choice for fascioliasis.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Triclabendazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1086440.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 50248.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.