Triparanol

CHEMBL187709 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

438.0 g/mol

LogP

6.2

Phase

4

Triparanol is a cholesterol synthesis inhibitor that blocks the conversion of desmosterol to cholesterol by inhibiting the enzyme delta-24-reductase late in the sterol biosynthesis pathway. It was developed as a lipid-lowering agent but was withdrawn from the market due to serious adverse effects including cataracts, ichthyosis, and alopecia caused by accumulation of desmosterol. It served as an early model for understanding cholesterol biosynthesis and drug design.

Molecular Weight

438.0000 g/mol

LogP

6.20

TPSA

32.70 Å²

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

CCN(CC)CCOc1ccc(C(O)(Cc2ccc(Cl)cc2)c2ccc(C)cc2)cc1

InChI

InChI=1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3

Molecular Formula

C27H32ClNO2

HBD / HBA

1 / 3

Rotatable Bonds

10

Heavy Atoms

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Triparanol is a cholesterol synthesis inhibitor that blocks the conversion of desmosterol to cholesterol by inhibiting the enzyme delta-24-reductase late in the sterol biosynthesis pathway. It was developed as a lipid-lowering agent but was withdrawn from the market due to serious adverse effects including cataracts, ichthyosis, and alopecia caused by accumulation of desmosterol. It served as an early model for understanding cholesterol biosynthesis and drug design.

Yes, Triparanol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL187709. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6536. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C27H32ClNO2

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.