Tripelennamine Citrate

CHEMBL1200769 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

447.5 g/mol

LogP

—

Phase

4

Tripelennamine citrate is the citrate salt of tripelennamine, a first-generation H1 antihistamine that blocks histamine receptors to alleviate allergic symptoms including rhinitis, urticaria, and pruritus. The citrate salt form provides improved solubility for oral liquid formulations. Like other first-generation antihistamines, it causes sedation due to CNS penetration.

Molecular Weight

447.5000 g/mol

TPSA

152.00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

CN(C)CCN(Cc1ccccc1)c1ccccn1.O=C(O)CC(O)(CC(=O)O)C(=O)O

InChI

InChI=1S/C16H21N3.C6H8O7/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-11H,12-14H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

Molecular Formula

C22H29N3O7

HBD / HBA

4 / 10

Rotatable Bonds

11

Heavy Atoms

32

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Tripelennamine citrate is the citrate salt of tripelennamine, a first-generation H1 antihistamine that blocks histamine receptors to alleviate allergic symptoms including rhinitis, urticaria, and pruritus. The citrate salt form provides improved solubility for oral liquid formulations. Like other first-generation antihistamines, it causes sedation due to CNS penetration.

Yes, Tripelennamine Citrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200769. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 197066. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C22H29N3O7

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.