Triprolidine Hydrochloride

CHEMBL3188034 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

314.9 g/mol

LogP

—

Phase

4

Triprolidine hydrochloride is the hydrochloride salt of triprolidine, a pyrrolidine-class first-generation H1 antihistamine used for relief of allergic rhinitis, urticaria, and cold symptoms. It blocks histamine at peripheral and central H1 receptors, producing antiallergic and sedative effects. This salt form is widely used in combination cold and allergy preparations.

Molecular Weight

314.9000 g/mol

TPSA

16.10 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1.Cl.O

InChI

InChI=1S/C19H22N2.ClH.H2O/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;;/h2-3,6-12H,4-5,13-15H2,1H3;1H;1H2/b18-11+;;

Molecular Formula

C19H23ClN2

HBD / HBA

1 / 2

Rotatable Bonds

4

Heavy Atoms

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Triprolidine hydrochloride is the hydrochloride salt of triprolidine, a pyrrolidine-class first-generation H1 antihistamine used for relief of allergic rhinitis, urticaria, and cold symptoms. It blocks histamine at peripheral and central H1 receptors, producing antiallergic and sedative effects. This salt form is widely used in combination cold and allergy preparations.

Yes, Triprolidine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3188034. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5702129. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C19H23ClN2
Synonyms: 38

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.