Urea C 14
Urea C-14 is a radioactively labeled form of urea containing carbon-14 used in the 14C-urea breath test for non-invasive detection of Helicobacter pylori infection in the stomach. H. pylori-produced urease hydrolyzes the ingested 14C-urea to produce 14CO2, which is measured in exhaled breath by liquid scintillation counting, indicating active infection. Unlike the 13C version, the 14C test involves low-level radiation exposure, limiting use in pregnant women and children.
Molecular Weight
62.0480 g/mol
LogP
-1.40
TPSA
69.10 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.
2D Structure
Cite this structure
Embed this structure
SMILES
N[14C](N)=O
InChI
InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)/i1+2
Molecular Formula
CH4N2O
HBD / HBA
2 / 1
Rotatable Bonds
0
Heavy Atoms
4
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Urea C-14 is a radioactively labeled form of urea containing carbon-14 used in the 14C-urea breath test for non-invasive detection of Helicobacter pylori infection in the stomach. H. pylori-produced urease hydrolyzes the ingested 14C-urea to produce 14CO2, which is measured in exhaled breath by liquid scintillation counting, indicating active infection. Unlike the 13C version, the 14C test involves low-level radiation exposure, limiting use in pregnant women and children.
Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.
Yes, Urea C 14 is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2096635. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11457650. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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