Vadadustat
Vadadustat is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor that stabilizes HIF-alpha subunits by blocking their hydroxylation and subsequent proteasomal degradation, thereby activating the physiological hypoxia response including increased erythropoietin production and red blood cell synthesis. It is used for the treatment of anemia associated with chronic kidney disease (CKD) in adults, offering an oral alternative to injectable erythropoiesis-stimulating agents (ESAs). Its mechanism mimics the body's natural adaptation to altitude and hypoxia.
Molecular Weight
306.7000 g/mol
LogP
2.50
TPSA
99.50 Ų
Lipinski RO5
Pass
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
O=C(O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O
InChI
InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
Molecular Formula
C14H11ClN2O4
HBD / HBA
3 / 5
Rotatable Bonds
4
Heavy Atoms
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Vadadustat is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor that stabilizes HIF-alpha subunits by blocking their hydroxylation and subsequent proteasomal degradation, thereby activating the physiological hypoxia response including increased erythropoietin production and red blood cell synthesis. It is used for the treatment of anemia associated with chronic kidney disease (CKD) in adults, offering an oral alternative to injectable erythropoiesis-stimulating agents (ESAs). Its mechanism mimics the body's natural adaptation to altitude and hypoxia.
Yes, Vadadustat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3646221. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 23634441. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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