Veratrum Viride Root
Veratrum viride (American hellebore) root contains steroidal alkaloids (jervine, veratrine, cyclopamine) that activate and then block voltage-gated sodium channels in cardiac and vascular tissue, producing bradycardia and hypotension. Historically, extracts were used as antihypertensive agents before modern therapies, but the narrow therapeutic window and potential for severe toxicity limited clinical use. Cyclopamine, derived from Veratrum californicum, has become important in cancer research as a Hedgehog pathway inhibitor.
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Veratrum viride (American hellebore) root contains steroidal alkaloids (jervine, veratrine, cyclopamine) that activate and then block voltage-gated sodium channels in cardiac and vascular tissue, producing bradycardia and hypotension. Historically, extracts were used as antihypertensive agents before modern therapies, but the narrow therapeutic window and potential for severe toxicity limited clinical use. Cyclopamine, derived from Veratrum californicum, has become important in cancer research as a Hedgehog pathway inhibitor.
Yes, Veratrum Viride Root is an approved drug. It has reached clinical phase 4. It is classified as a Unknown.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201531. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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