Von Willebrand Factor Human
Human von Willebrand factor (VWF) is a large multimeric glycoprotein derived from plasma that mediates platelet adhesion to damaged subendothelium via interaction with collagen and platelet glycoprotein Ib-IX-V, and stabilizes and protects coagulation factor VIII from proteolytic degradation. Plasma-derived VWF concentrates are used for the treatment of von Willebrand disease (VWD) when desmopressin is insufficient, particularly for surgical prophylaxis and management of severe bleeding. VWF levels also influence risk in cardiovascular and pulmonary conditions.
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Human von Willebrand factor (VWF) is a large multimeric glycoprotein derived from plasma that mediates platelet adhesion to damaged subendothelium via interaction with collagen and platelet glycoprotein Ib-IX-V, and stabilizes and protects coagulation factor VIII from proteolytic degradation. Plasma-derived VWF concentrates are used for the treatment of von Willebrand disease (VWD) when desmopressin is insufficient, particularly for surgical prophylaxis and management of severe bleeding. VWF levels also influence risk in cardiovascular and pulmonary conditions.
Yes, Von Willebrand Factor Human is an approved drug. It has reached clinical phase 4. It is classified as a Unknown.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4298126. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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