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Zipeprol

CHEMBL2105497 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
384.5 g/mol
LogP
2.2
Phase
4

Zipeprol is a centrally acting antitussive agent that suppresses cough through mechanisms involving both central opioid receptor activity and local anesthetic properties, rather than acting primarily on the cough center as codeine does. It has been used in some countries for symptomatic relief of non-productive cough associated with respiratory tract infections. Its potential for abuse and dependence due to opioid-related psychotropic effects led to restrictions or withdrawal in many markets.

Molecular Weight

384.5000 g/mol

LogP

2.20

TPSA

45.20 Ų

Lipinski RO5

Pass

Mechanism of Action

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COC(CN1CCN(CC(O)C(OC)c2ccccc2)CC1)c1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C23H32N2O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
Rotatable Bonds

                        
9

                    

                    
                    
                    

                        
Heavy Atoms

                        
28

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Zipeprol is a centrally acting antitussive agent that suppresses cough through mechanisms involving both central opioid receptor activity and local anesthetic properties, rather than acting primarily on the cough center as codeine does. It has been used in some countries for symptomatic relief of non-productive cough associated with respiratory tract infections. Its potential for abuse and dependence due to opioid-related psychotropic effects led to restrictions or withdrawal in many markets.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Zipeprol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2105497.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 36910.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.