Digoxin vs Tofacitinib

## Digoxin vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Digoxin** and **Tofacitinib**.

## Mechanism of Action

**Digoxin**: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Digoxin — 36-48 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Digoxin — C41H64O14; Tofacitinib — C16H20N6O.

**Molecular Weight**: Digoxin — 780.9430 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Digoxin — Small molecule; Tofacitinib — Small molecule.