Adapalene
A topical retinoid gel or cream applied to the skin to treat acne by normalizing the shedding of skin cells inside hair follicles, preventing the blockages that lead to blackheads, whiteheads, and inflammatory pimples. It also has anti-inflammatory properties that help reduce redness and swelling around acne lesions. Skin irritation and dryness are common at the start of treatment and usually improve after several weeks of consistent use.
Peso molecular
412,5000 g/mol
LogP
7,70
TPSA
46,50 Ų
Regla de cinco de Lipinski
Cumple
Mecanismo de acción
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Estructura 2D
Cite this structure
Embed this structure
SMILES
COc1ccc(-c2ccc3cc(C(=O)O)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2
InChI
InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
Molecular Formula
C28H28O3
HBD / HBA
1 / 3
Enlaces Rotables
4
Átomos Pesados
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A topical retinoid gel or cream applied to the skin to treat acne by normalizing the shedding of skin cells inside hair follicles, preventing the blockages that lead to blackheads, whiteheads, and inflammatory pimples. It also has anti-inflammatory properties that help reduce redness and swelling around acne lesions. Skin irritation and dryness are common at the start of treatment and usually improve after several weeks of consistent use.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Adapalene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1265. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60164. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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