Busulfan
An alkylating agent used to condition patients for bone marrow transplantation by destroying the existing bone marrow and suppressing the immune system to allow engraftment. It is also used in the treatment of chronic myelogenous leukemia. Major side effects include severe bone marrow suppression, pulmonary toxicity, and risk of secondary cancers.
Peso molecular
246,3000 g/mol
LogP
-0,50
TPSA
104,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CS(=O)(=O)OCCCCOS(C)(=O)=O
InChI
InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
Molecular Formula
C6H14O6S2
HBD / HBA
- / 6
Enlaces Rotables
7
Átomos Pesados
14
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
An alkylating agent used to condition patients for bone marrow transplantation by destroying the existing bone marrow and suppressing the immune system to allow engraftment. It is also used in the treatment of chronic myelogenous leukemia. Major side effects include severe bone marrow suppression, pulmonary toxicity, and risk of secondary cancers.
Forms covalent bonds with DNA bases, creating cross-links and strand breaks that prevent DNA replication and transcription. This triggers apoptosis in rapidly dividing cells, particularly cancer cells.
Yes, Busulfan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL820. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2478. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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