Calcifediol
A form of vitamin D that is the primary circulating storage form in the body, also known as 25-hydroxyvitamin D. It is used to treat secondary hyperparathyroidism and bone disease in patients with chronic kidney disease who have vitamin D deficiency. Unlike cholecalciferol, it does not require liver activation, making it useful in patients with liver disease.
Peso molecular
400,6000 g/mol
LogP
6,20
TPSA
40,50 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Estructura 2D
Cite this structure
Embed this structure
SMILES
C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]12.O
InChI
InChI=1S/C27H44O2.H2O/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29;/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3;1H2/b21-11+,22-12-;/t20-,23+,24-,25+,27-;/m1./s1
Molecular Formula
C27H44O2
HBD / HBA
2 / 2
Enlaces Rotables
6
Átomos Pesados
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A form of vitamin D that is the primary circulating storage form in the body, also known as 25-hydroxyvitamin D. It is used to treat secondary hyperparathyroidism and bone disease in patients with chronic kidney disease who have vitamin D deficiency. Unlike cholecalciferol, it does not require liver activation, making it useful in patients with liver disease.
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Yes, Calcifediol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3544909. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5283731. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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