Ciprofloxacin Hydrochloride
The hydrochloride salt is the most widely used formulation of ciprofloxacin, available in oral tablets, suspension, intravenous solution, and ophthalmic preparations. It provides the same broad-spectrum fluoroquinolone antibacterial coverage as the parent compound. Concomitant antacids and divalent cation supplements should be avoided as they reduce oral bioavailability through chelation.
Peso molecular
385,8000 g/mol
TPSA
73,90 Ų
Áreas terapéuticas
Mecanismo de acción
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Estructura 2D
Cite this structure
Embed this structure
SMILES
Cl.O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O
InChI
InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
Molecular Formula
C17H21ClFN3O4
HBD / HBA
4 / 8
Enlaces Rotables
3
Átomos Pesados
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
The hydrochloride salt is the most widely used formulation of ciprofloxacin, available in oral tablets, suspension, intravenous solution, and ophthalmic preparations. It provides the same broad-spectrum fluoroquinolone antibacterial coverage as the parent compound. Concomitant antacids and divalent cation supplements should be avoided as they reduce oral bioavailability through chelation.
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Yes, Ciprofloxacin Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1202. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 62998. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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