Cytarabine
A pyrimidine nucleoside analogue that interferes with DNA synthesis by inhibiting DNA polymerase, used primarily to treat acute myeloid leukemia and other hematologic malignancies. It is often given in high-dose regimens and can cause cerebellar toxicity.
Peso molecular
243,2200 g/mol
LogP
-2,10
TPSA
129,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Estructura 2D
Cite this structure
Embed this structure
SMILES
Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1
InChI
InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
Molecular Formula
C9H13N3O5
HBD / HBA
4 / 5
Enlaces Rotables
2
Átomos Pesados
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A pyrimidine nucleoside analogue that interferes with DNA synthesis by inhibiting DNA polymerase, used primarily to treat acute myeloid leukemia and other hematologic malignancies. It is often given in high-dose regimens and can cause cerebellar toxicity.
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Yes, Cytarabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL803. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6253. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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