Diphenhydramine Hydrochloride
The hydrochloride salt form of diphenhydramine, the most widely used pharmaceutical form found in oral tablets, capsules, liquid preparations, and topical formulations. It provides the same antihistamine, sedative, and anticholinergic effects as the parent compound. It is the active ingredient in many over-the-counter sleep aids and allergy medications.
Peso molecular
291,8000 g/mol
TPSA
12,50 Ų
Áreas terapéuticas
Mecanismo de acción
First-generation H1 antihistamine with anticholinergic properties.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
First-generation H1 antihistamine with anticholinergic properties.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CN(C)CCOC(c1ccccc1)c1ccccc1.Cl
InChI
InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
Molecular Formula
C17H22ClNO
HBD / HBA
1 / 2
Enlaces Rotables
6
Átomos Pesados
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
The hydrochloride salt form of diphenhydramine, the most widely used pharmaceutical form found in oral tablets, capsules, liquid preparations, and topical formulations. It provides the same antihistamine, sedative, and anticholinergic effects as the parent compound. It is the active ingredient in many over-the-counter sleep aids and allergy medications.
First-generation H1 antihistamine with anticholinergic properties.
Yes, Diphenhydramine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1620. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 8980. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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