Ifosfamide
This alkylating chemotherapy agent works by cross-linking DNA strands within cancer cells, preventing them from replicating. It is used to treat a variety of cancers including sarcomas, testicular cancer, and lymphomas. A key concern is ifosfamide-induced hemorrhagic cystitis (bladder irritation), which is prevented by co-administering the protective agent mesna.
Peso molecular
261,0800 g/mol
LogP
0,90
TPSA
41,60 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
O=P1(NCCCl)OCCCN1CCCl
InChI
InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
Molecular Formula
C7H15Cl2N2O2P
HBD / HBA
1 / 4
Enlaces Rotables
5
Átomos Pesados
14
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This alkylating chemotherapy agent works by cross-linking DNA strands within cancer cells, preventing them from replicating. It is used to treat a variety of cancers including sarcomas, testicular cancer, and lymphomas. A key concern is ifosfamide-induced hemorrhagic cystitis (bladder irritation), which is prevented by co-administering the protective agent mesna.
Yes, Ifosfamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1024. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3690. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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