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Primaquine Phosphate

CHEMBL43128 Phase 4 Aprobado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
455.3 g/mol
LogP
—
Phase
4

Dormant liver stages are the reason primaquine phosphate occupies a distinct position in antimalarial therapy. Plasmodium vivax and Plasmodium ovale leave hypnozoites in hepatocytes that can reactivate weeks or months after the initial illness, and this agent eliminates them, preventing the relapses that blood-stage treatment alone cannot avert. It is used both for that radical cure and for prevention of the infections concerned. The phosphate salt carries the therapeutic properties of primaquine itself without altering them. Chemically the salt is recorded as C15H27N3O9P2 with a formula mass close to 455.3 g/mol. It is an approved small-molecule antiparasitic agent developed through the final clinical phase.

A phosphate salt form of primaquine with the same therapeutic properties. An antiparasitic medication used to treat and prevent certain types of malaria, particularly to eliminate the dormant liver stages of Plasmodium vivax and Plasmodium ovale that can cause the infection to relapse weeks or months later.

Peso molecular

455,3400 g/mol

TPSA

216,00 Ų

Áreas terapéuticas

Malaria

Mecanismo de acción

An 8-aminoquinoline antimalarial. Primaquine is metabolised to redox-active quinoline-quinones that generate reactive oxygen species and disrupt the parasite's mitochondrial electron transport chain, killing the hepatic hypnozoites of Plasmodium vivax and P. ovale that cause relapse, as well as gametocytes. The same oxidative chemistry causes haemolysis in people with glucose-6-phosphate dehydrogenase deficiency.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

An 8-aminoquinoline antimalarial. Primaquine is metabolised to redox-active quinoline-quinones that generate reactive oxygen species and disrupt the parasite's mitochondrial electron transport chain, killing the hepatic hypnozoites of Plasmodium vivax and …

Estructura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1cc(NC(C)CCCN)c2ncccc2c1.O=P(O)(O)O.O=P(O)(O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H27N3O9P2

                    

                    
                    

                        
HBD / HBA

                        
8 / 12

                    

                    
                    

                        
Enlaces Rotables

                        
6

                    

                    
                    
                    

                        
Átomos Pesados

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Preguntas frecuentes

                

                    
                    

                        
                        

                            
A phosphate salt form of primaquine with the same therapeutic properties. An antiparasitic medication used to treat and prevent certain types of malaria, particularly to eliminate the dormant liver stages of Plasmodium vivax and Plasmodium ovale that can cause the infection to relapse weeks or months later.

                        

                    

                    

                    

                    
                    

                        
                        

                            
An 8-aminoquinoline antimalarial. Primaquine is metabolised to redox-active quinoline-quinones that generate reactive oxygen species and disrupt the parasite's mitochondrial electron transport chain, killing the hepatic hypnozoites of Plasmodium vivax and P. ovale that cause relapse, as well as gametocytes. The same oxidative chemistry causes haemolysis in people with glucose-6-phosphate dehydrogenase deficiency.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Primaquine Phosphate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL43128.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6135.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
Aviso médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.