Rivaroxaban
A direct oral anticoagulant that inhibits Factor Xa, used to prevent and treat blood clots in conditions such as atrial fibrillation, deep vein thrombosis, and pulmonary embolism. Unlike warfarin, it requires no routine blood monitoring and has fewer food and drug interactions.
Peso molecular
435,8820 g/mol
LogP
2,50
TPSA
116,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Clases de fármacos
Mecanismo de acción
Direct Factor Xa inhibitor.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Direct Factor Xa inhibitor.
Estructura 2D
Cite this structure
Embed this structure
SMILES
O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)c1ccc(Cl)s1
InChI
InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
Molecular Formula
C19H18ClN3O5S
HBD / HBA
1 / 6
Enlaces Rotables
5
Átomos Pesados
29
Combining rivaroxaban with clopidogrel substantially increases bleeding risk through simultaneous inhibition of factor Xa and platelet P2Y12 receptors.
Fluconazole markedly increases rivaroxaban exposure through dual inhibition of CYP3A4 and P-glycoprotein, substantially elevating bleeding risk.
Cyclosporine, a strong dual inhibitor of CYP3A4 and P-glycoprotein, substantially increases rivaroxaban exposure and bleeding risk.
Adding aspirin to rivaroxaban increases bleeding risk through additive antithrombotic effects; some indications (COMPASS trial) use this combination with careful patient selection.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A direct oral anticoagulant that inhibits Factor Xa, used to prevent and treat blood clots in conditions such as atrial fibrillation, deep vein thrombosis, and pulmonary embolism. Unlike warfarin, it requires no routine blood monitoring and has fewer food and drug interactions.
Direct Factor Xa inhibitor.
Key pharmacokinetic parameters for Rivaroxaban: Half-life: 5-9 hours.
Yes, Rivaroxaban is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
Same Target
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL198362. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9875401. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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