CYP3A4 (Citocromo P450 3A4 (CYP3A4))
CYP3A4
La enzima CYP hepática más abundante, que metaboliza aproximadamente el 50% de todos los fármacos comercializados.
Función
La inducción (rifampicina) o inhibición (ketoconazol, pomelo) de CYP3A4 causa importantes interacciones fármaco-fármaco.
Fármacos que actúan sobre esta diana
| Fármaco | Acción | Principal |
|---|---|---|
| Carbamazepine | Inducer | — |
| Phenytoin | Inducer | — |
| Fluconazole | Inhibitor | — |
| Diltiazem | Inhibitor | — |
| Clopidogrel | Substrate | — |
| Diazepam | Substrate | — |
| Alprazolam | Substrate | — |
| Zolpidem | Substrate | — |
| Apixaban | Substrate | — |
| Rivaroxaban | Substrate | — |
| Sildenafil | Substrate | — |
| Donepezil | Substrate | — |
| Colchicine | Substrate | — |
| Cyclosporine | Substrate | — |
| Atorvastatin | Substrate | — |
| Tacrolimus | Substrate | — |
| Losartan | Substrate | — |
| Simvastatin | Substrate | — |
| Warfarin | Substrate | — |
Related Targets
ATP4A (Bomba de protones (H+/K+-ATPasa))
ATP4A
PTGS1 (Ciclooxigenasa-1 (COX-1))
PTGS1
PTGS2 (Ciclooxigenasa-2 (COX-2))
PTGS2
CYP2D6 (Citocromo P450 2D6 (CYP2D6))
CYP2D6
ACE (Enzima convertidora de angiotensina (ECA))
ACE
VKORC1 (Epóxido reductasa de vitamina K (VKORC1))
VKORC1
PDE5A (Fosfodiesterasa 5 (PDE5))
PDE5A
HMGCR (HMG-CoA reductasa)
HMGCR