CYP3A4 (Cytochrome P450 3A4)
CYP3A4
The most abundant hepatic CYP enzyme, metabolizing ~50% of all marketed drugs.
Function
CYP3A4 induction (rifampin) or inhibition (ketoconazole, grapefruit) causes major drug-drug interactions.
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Carbamazepine | Inducer | — |
| Phenytoin | Inducer | — |
| Fluconazole | Inhibitor | — |
| Diltiazem | Inhibitor | — |
| Clopidogrel | Substrate | — |
| Diazepam | Substrate | — |
| Alprazolam | Substrate | — |
| Zolpidem | Substrate | — |
| Apixaban | Substrate | — |
| Rivaroxaban | Substrate | — |
| Sildenafil | Substrate | — |
| Donepezil | Substrate | — |
| Colchicine | Substrate | — |
| Cyclosporine | Substrate | — |
| Atorvastatin | Substrate | — |
| Tacrolimus | Substrate | — |
| Losartan | Substrate | — |
| Simvastatin | Substrate | — |
| Warfarin | Substrate | — |