HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
Function
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Atorvastatin | Inhibitor | Yes |
| Simvastatin | Inhibitor | Yes |
| Rosuvastatin | Inhibitor | Yes |
| Pravastatin | Inhibitor | Yes |