PTGS2 (Cyclooxygenase-2)
PTGS2
Inducible cyclooxygenase isoform upregulated during inflammation and pain signaling.
Function
Catalyzes prostaglandin H2 synthesis at sites of inflammation. Primary target of NSAIDs and selective COX-2 inhibitors (coxibs).
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Celecoxib | Inhibitor | Yes |
| Ibuprofen | Inhibitor | Yes |
| Naproxen | Inhibitor | Yes |
| Acetaminophen | Inhibitor | Yes |
| Aspirin | Inhibitor | — |