PTGS1 (Cyclooxygenase-1)
PTGS1
Constitutive cyclooxygenase isoform catalyzing prostaglandin synthesis for homeostatic functions.
Function
Converts arachidonic acid to prostaglandin H2, the precursor for thromboxane A2 (platelet aggregation) and cytoprotective prostaglandins in the gastric mucosa.
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Aspirin | Inhibitor | Yes |
| Acetaminophen | Inhibitor | — |
| Ibuprofen | Inhibitor | — |
| Naproxen | Inhibitor | — |