Tetrazepam
Tetrazepam is a benzodiazepine with muscle relaxant, anxiolytic, and anticonvulsant properties that acts by potentiating GABA-A receptor-mediated chloride ion influx, enhancing inhibitory neurotransmission in the central nervous system. It was used as a muscle relaxant for treatment of painful skeletal muscle spasms and was withdrawn from several markets due to serious cutaneous adverse reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Its muscle relaxant activity was considered clinically useful but the severe dermatological risks outweighed benefits.
Peso molecular
288,7700 g/mol
LogP
3,20
TPSA
32,70 Ų
Regla de cinco de Lipinski
Cumple
Mecanismo de acción
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
Estructura 2D
Cite this structure
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SMILES
CN1C(=O)CN=C(C2=CCCCC2)c2cc(Cl)ccc21
InChI
InChI=1S/C16H17ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h5,7-9H,2-4,6,10H2,1H3
Molecular Formula
C16H17ClN2O
HBD / HBA
- / 2
Enlaces Rotables
1
Átomos Pesados
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Tetrazepam is a benzodiazepine with muscle relaxant, anxiolytic, and anticonvulsant properties that acts by potentiating GABA-A receptor-mediated chloride ion influx, enhancing inhibitory neurotransmission in the central nervous system. It was used as a muscle relaxant for treatment of painful skeletal muscle spasms and was withdrawn from several markets due to serious cutaneous adverse reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Its muscle relaxant activity was considered clinically useful but the severe dermatological risks outweighed benefits.
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
Yes, Tetrazepam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105527. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25215. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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