Thiabendazole
Thiabendazole is a benzimidazole anthelmintic that inhibits the helminth-specific enzyme fumarate reductase and interferes with microtubule assembly by binding to beta-tubulin, disrupting energy metabolism and cellular structure in parasitic nematodes. It is used for treatment of strongyloidiasis, cutaneous larva migrans, and visceral larva migrans, and is also used as an antifungal agent in agriculture. Its broad antiparasitic spectrum and mechanism of action on parasite-specific metabolic pathways provide selectivity over mammalian cells.
Peso molecular
201,2500 g/mol
LogP
2,50
TPSA
69,80 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Estructura 2D
Cite this structure
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SMILES
c1ccc2[nH]c(-c3cscn3)nc2c1
InChI
InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
Molecular Formula
C10H7N3S
HBD / HBA
1 / 3
Enlaces Rotables
1
Átomos Pesados
14
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Thiabendazole is a benzimidazole anthelmintic that inhibits the helminth-specific enzyme fumarate reductase and interferes with microtubule assembly by binding to beta-tubulin, disrupting energy metabolism and cellular structure in parasitic nematodes. It is used for treatment of strongyloidiasis, cutaneous larva migrans, and visceral larva migrans, and is also used as an antifungal agent in agriculture. Its broad antiparasitic spectrum and mechanism of action on parasite-specific metabolic pathways provide selectivity over mammalian cells.
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Yes, Thiabendazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL625. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5430. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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