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Thiabendazole

CHEMBL625 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
201.2 g/mol
LogP
2.5
Phase
4

Thiabendazole is a benzimidazole anthelmintic that inhibits the helminth-specific enzyme fumarate reductase and interferes with microtubule assembly by binding to beta-tubulin, disrupting energy metabolism and cellular structure in parasitic nematodes. It is used for treatment of strongyloidiasis, cutaneous larva migrans, and visceral larva migrans, and is also used as an antifungal agent in agriculture. Its broad antiparasitic spectrum and mechanism of action on parasite-specific metabolic pathways provide selectivity over mammalian cells.

น้ำหนักโมเลกุล

201.2500 g/mol

LogP

2.50

TPSA

69.80 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Breast Cancer Prostate Cancer Colorectal Cancer

กลไกการออกฤทธิ์

Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
c1ccc2[nH]c(-c3cscn3)nc2c1

                

                

                
                

                    
InChI

                    
InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H7N3S

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
พันธะที่หมุนได้

                        
1

                    

                    
                    
                    

                        
อะตอมหนัก

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Thiabendazole is a benzimidazole anthelmintic that inhibits the helminth-specific enzyme fumarate reductase and interferes with microtubule assembly by binding to beta-tubulin, disrupting energy metabolism and cellular structure in parasitic nematodes. It is used for treatment of strongyloidiasis, cutaneous larva migrans, and visceral larva migrans, and is also used as an antifungal agent in agriculture. Its broad antiparasitic spectrum and mechanism of action on parasite-specific metabolic pathways provide selectivity over mammalian cells.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Thiabendazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL625.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5430.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.