Trazodone
This antidepressant medication is prescribed for depression and is widely used off-label to treat insomnia because of its sedating properties. It works primarily by blocking serotonin receptors and inhibiting serotonin reuptake in the brain, with relatively little effect on other neurotransmitters. Unlike many sleep aids, it is generally not habit-forming.
Peso molecular
371,8640 g/mol
LogP
2,80
TPSA
42,40 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Clases de fármacos
Mecanismo de acción
Serotonin antagonist and reuptake inhibitor (SARI).
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Serotonin antagonist and reuptake inhibitor (SARI).
Estructura 2D
Cite this structure
Embed this structure
SMILES
O=c1n(CCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12
InChI
InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
Molecular Formula
C19H22ClN5O
HBD / HBA
- / 4
Enlaces Rotables
5
Átomos Pesados
26
Sertraline combined with trazodone may increase the risk of serotonin syndrome due to additive serotonergic effects.
Fluoxetine inhibits CYP2D6-mediated metabolism of trazodone, significantly increasing trazodone plasma levels and serotonin syndrome risk.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This antidepressant medication is prescribed for depression and is widely used off-label to treat insomnia because of its sedating properties. It works primarily by blocking serotonin receptors and inhibiting serotonin reuptake in the brain, with relatively little effect on other neurotransmitters. Unlike many sleep aids, it is generally not habit-forming.
Serotonin antagonist and reuptake inhibitor (SARI).
Key pharmacokinetic parameters for Trazodone: Half-life: 5-9 hours.
Yes, Trazodone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL621. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5533. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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