Descripción

Fluoxetine inhibits CYP2D6-mediated metabolism of trazodone, significantly increasing trazodone plasma levels and serotonin syndrome risk.

Mecanismo

Fluoxetine potently inhibits CYP2D6, the primary enzyme metabolizing trazodone, raising trazodone AUC; additive serotonergic activity further increases toxicity risk.

Relevancia clínica

Trazodone toxicity (excessive sedation, serotonin syndrome) has been documented when combined with fluoxetine.

Manejo clínico

Reduce trazodone dose by 50% when adding fluoxetine; monitor for sedation and serotonin syndrome symptoms.

Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.