Moderate
Probable
描述
Fluoxetine inhibits CYP2D6-mediated metabolism of trazodone, significantly increasing trazodone plasma levels and serotonin syndrome risk.
机制
Fluoxetine potently inhibits CYP2D6, the primary enzyme metabolizing trazodone, raising trazodone AUC; additive serotonergic activity further increases toxicity risk.
临床意义
Trazodone toxicity (excessive sedation, serotonin syndrome) has been documented when combined with fluoxetine.
处理措施
Reduce trazodone dose by 50% when adding fluoxetine; monitor for sedation and serotonin syndrome symptoms.