Vinorelbine
This semi-synthetic vinca alkaloid chemotherapy is used to treat non-small cell lung cancer and breast cancer, either alone or in combination with other chemotherapy agents. Like other vinca alkaloids, it works by blocking cell division by preventing the formation of the mitotic spindle in cancer cells. It can be given intravenously or as an oral capsule, and peripheral neuropathy and bone marrow suppression are the main side effects.
Peso molecular
778,9000 g/mol
LogP
3,60
TPSA
134,00 Ų
Regla de cinco de Lipinski
No cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2
InChI
InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45-/m0/s1
Molecular Formula
C45H54N4O8
HBD / HBA
2 / 11
Enlaces Rotables
10
Átomos Pesados
57
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This semi-synthetic vinca alkaloid chemotherapy is used to treat non-small cell lung cancer and breast cancer, either alone or in combination with other chemotherapy agents. Like other vinca alkaloids, it works by blocking cell division by preventing the formation of the mitotic spindle in cancer cells. It can be given intravenously or as an oral capsule, and peripheral neuropathy and bone marrow suppression are the main side effects.
Yes, Vinorelbine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL553025. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5311497. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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