Zimeldine
Zimeldine was the first selective serotonin reuptake inhibitor (SSRI) to reach clinical use, blocking the serotonin transporter (SERT) to inhibit synaptic serotonin reuptake and increase serotonergic neurotransmission for antidepressant effect. It was the prototype SSRI that established the therapeutic validity of selective serotonin reuptake inhibition. It was withdrawn worldwide due to serious hypersensitivity reactions including Guillain-Barré syndrome, but it paved the way for the development of subsequent SSRIs.
Peso molecular
317,2200 g/mol
LogP
3,90
TPSA
16,10 Ų
Regla de cinco de Lipinski
Cumple
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1
InChI
InChI=1S/C16H17BrN2/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13/h3-10,12H,11H2,1-2H3/b16-9-
Molecular Formula
C16H17BrN2
HBD / HBA
- / 2
Enlaces Rotables
4
Átomos Pesados
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Zimeldine was the first selective serotonin reuptake inhibitor (SSRI) to reach clinical use, blocking the serotonin transporter (SERT) to inhibit synaptic serotonin reuptake and increase serotonergic neurotransmission for antidepressant effect. It was the prototype SSRI that established the therapeutic validity of selective serotonin reuptake inhibition. It was withdrawn worldwide due to serious hypersensitivity reactions including Guillain-Barré syndrome, but it paved the way for the development of subsequent SSRIs.
Yes, Zimeldine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL37744. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5365247. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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