Zimeldine
Zimeldine was the first selective serotonin reuptake inhibitor (SSRI) to reach clinical use, blocking the serotonin transporter (SERT) to inhibit synaptic serotonin reuptake and increase serotonergic neurotransmission for antidepressant effect. It was the prototype SSRI that established the therapeutic validity of selective serotonin reuptake inhibition. It was withdrawn worldwide due to serious hypersensitivity reactions including Guillain-Barré syndrome, but it paved the way for the development of subsequent SSRIs.
分子量
317.2200 g/mol
LogP
3.90
TPSA
16.10 Ų
Lipinski 五规则
符合
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1
InChI
InChI=1S/C16H17BrN2/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13/h3-10,12H,11H2,1-2H3/b16-9-
Molecular Formula
C16H17BrN2
HBD / HBA
- / 2
可旋转键数
4
重原子数
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Zimeldine was the first selective serotonin reuptake inhibitor (SSRI) to reach clinical use, blocking the serotonin transporter (SERT) to inhibit synaptic serotonin reuptake and increase serotonergic neurotransmission for antidepressant effect. It was the prototype SSRI that established the therapeutic validity of selective serotonin reuptake inhibition. It was withdrawn worldwide due to serious hypersensitivity reactions including Guillain-Barré syndrome, but it paved the way for the development of subsequent SSRIs.
Yes, Zimeldine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL37744. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5365247. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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