Bioavailability (F)
FThe fraction of an administered dose that reaches the systemic circulation in unchanged form. IV administration has 100% bioavailability by definition. Oral bioavailability is reduced by first-pass metabolism and incomplete absorption.
Ejemplos
- Morphine oral F ~30%
- Atorvastatin F ~14%
- IV always F = 1.0
¿Sabías que...?
The fraction of an administered dose that reaches the systemic circulation in unchanged form. IV administration has 100% bioavailability by definition. Oral bioavailability is reduced by first-pass metabolism and incomplete …