Quantal Dose-Response

A population-level relationship between drug dose and the proportion of individuals exhibiting an all-or-none response (e.g., seizure, sleep, death), plotted as a cumulative frequency distribution. Quantal dose-response analysis yields the ED50 (median effective dose), TD50 (median toxic dose), and LD50. The ratio of TD50 to ED50 defines the therapeutic index for the population.

Ejemplos

• ED50 of a hypnotic: dose at which 50% of subjects fall asleep
• LD50 determination in preclinical toxicology for calculating therapeutic index
• Probit analysis of quantal data for anesthetic MAC (minimum alveolar concentration) determination