Tachyphylaxis

Pharmacodynamics

Rapid decrease in drug response after repeated administration over a short period. Distinguished from tolerance by its acute onset. Often involves depletion of neurotransmitter stores.

Ejemplos

  • Indirect sympathomimetics (ephedrine)
  • Nitrate tolerance
  • Nicotine (acute)

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Rapid decrease in drug response after repeated administration over a short period. Distinguished from tolerance by its acute onset. Often involves depletion of neurotransmitter stores.