Therapeutic Index (TI)

Pharmacodynamics

The ratio of the toxic dose to the therapeutic dose (TD50/ED50 or LD50/ED50). A narrow therapeutic index means small dose changes can cause toxicity or loss of efficacy, requiring close monitoring.

Ejemplos

Lithium (NTI drug)
Warfarin (NTI drug)
Digoxin (NTI drug)

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The ratio of the toxic dose to the therapeutic dose (TD50/ED50 or LD50/ED50). A narrow therapeutic index means small dose changes can cause toxicity or loss of efficacy, requiring close …