Descripción

Naproxen combined with sertraline increases the risk of upper GI bleeding through complementary impairment of platelet function and gastric mucosal defense.

Mecanismo

Sertraline depletes platelet serotonin stores, reducing aggregation; naproxen inhibits COX-1 and damages gastric mucosa. The combination amplifies GI hemorrhagic risk.

Relevancia clínica

Epidemiological studies show a 12–15-fold increase in upper GI bleed risk with NSAID + SSRI combined.

Manejo clínico

Co-prescribe a PPI; prefer acetaminophen over NSAIDs in patients on SSRIs; educate patient about GI bleeding warning signs.

Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.