Acitretin
An oral retinoid medication derived from vitamin A that is used to treat severe psoriasis and other serious skin disorders by regulating abnormal skin cell growth and reducing inflammation. It is highly effective for pustular and erythrodermic psoriasis but requires strict pregnancy prevention because it causes severe birth defects; women must avoid pregnancy for three years after stopping treatment. Regular blood tests to monitor liver function and blood lipid levels are essential during therapy.
Masse moléculaire
326,4000 g/mol
LogP
6,10
TPSA
46,50 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Structure 2D
Cite this structure
Embed this structure
SMILES
COc1cc(C)c(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)c(C)c1C
InChI
InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
Molecular Formula
C21H26O3
HBD / HBA
1 / 3
Liaisons Rotatives
6
Atomes Lourds
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
An oral retinoid medication derived from vitamin A that is used to treat severe psoriasis and other serious skin disorders by regulating abnormal skin cell growth and reducing inflammation. It is highly effective for pustular and erythrodermic psoriasis but requires strict pregnancy prevention because it causes severe birth defects; women must avoid pregnancy for three years after stopping treatment. Regular blood tests to monitor liver function and blood lipid levels are essential during therapy.
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Yes, Acitretin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1131. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5284513. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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