Adalimumab
A biologic injection that targets and neutralizes a protein called TNF-alpha, which drives inflammation in a wide range of autoimmune and inflammatory conditions. It is used for rheumatoid arthritis, psoriasis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, and other immune-mediated diseases. Before starting treatment, patients are screened for tuberculosis and hepatitis B, and they should avoid live vaccines throughout therapy.
Aires thérapeutiques
Classes de médicaments
Mécanisme d'action
Fully human anti-TNF-alpha monoclonal antibody.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Fully human anti-TNF-alpha monoclonal antibody.
HBD / HBA
- / -
Methotrexate is intentionally combined with adalimumab in rheumatoid arthritis and other autoimmune conditions to reduce adalimumab immunogenicity and improve efficacy; co-administration requires monitoring for additive immunosuppression.
Azithromycin may interact modestly with adalimumab-treated patients through immunomodulatory properties, though direct pharmacokinetic interaction is minimal and the combination is used routinely in clinical practice.
Combining adalimumab with cyclosporine produces substantial additive immunosuppression, increasing the risk of serious opportunistic infections, lymphoma, and other immunosuppression-related malignancies.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A biologic injection that targets and neutralizes a protein called TNF-alpha, which drives inflammation in a wide range of autoimmune and inflammatory conditions. It is used for rheumatoid arthritis, psoriasis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, and other immune-mediated diseases. Before starting treatment, patients are screened for tuberculosis and hepatitis B, and they should avoid live vaccines throughout therapy.
Fully human anti-TNF-alpha monoclonal antibody.
Key pharmacokinetic parameters for Adalimumab: Half-life: 14 days.
Yes, Adalimumab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.
Related Drugs
Same Drug Class
Same Target
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201580. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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