Bictegravir
An integrase strand transfer inhibitor used to treat HIV-1 infection as part of combination antiretroviral therapy. It prevents the virus from inserting its genetic material into human cells. It is typically formulated as a fixed-dose combination tablet taken once daily.
Masse moléculaire
449,4000 g/mol
LogP
2,70
TPSA
99,20 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.
Structure 2D
Cite this structure
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SMILES
O=C(NCc1c(F)cc(F)cc1F)c1cn2c(c(O)c1=O)C(=O)N1[C@H]3CC[C@H](C3)O[C@@H]1C2
InChI
InChI=1S/C21H18F3N3O5/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30)/t10-,11+,16+/m0/s1
Molecular Formula
C21H18F3N3O5
HBD / HBA
2 / 9
Liaisons Rotatives
3
Atomes Lourds
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
An integrase strand transfer inhibitor used to treat HIV-1 infection as part of combination antiretroviral therapy. It prevents the virus from inserting its genetic material into human cells. It is typically formulated as a fixed-dose combination tablet taken once daily.
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.
Yes, Bictegravir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989866. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 90311989. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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