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Bictegravir

CHEMBL3989866 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
449.4 g/mol
LogP
2.7
Phase
4

An integrase strand transfer inhibitor used to treat HIV-1 infection as part of combination antiretroviral therapy. It prevents the virus from inserting its genetic material into human cells. It is typically formulated as a fixed-dose combination tablet taken once daily.

Berat Molekul

449,4000 g/mol

LogP

2,70

TPSA

99,20 Ų

Lipinski RO5

Lulus

Area Terapeutik

Cardiovascular Disease Rheumatoid Arthritis Osteoporosis Generalized Anxiety Disorder Obesity HIV/AIDS Hepatitis C Tuberculosis Heart Failure

Mekanisme Kerja

Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(NCc1c(F)cc(F)cc1F)c1cn2c(c(O)c1=O)C(=O)N1[C@H]3CC[C@H](C3)O[C@@H]1C2

                

                

                
                

                    
InChI

                    
InChI=1S/C21H18F3N3O5/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30)/t10-,11+,16+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H18F3N3O5

                    

                    
                    

                        
HBD / HBA

                        
2 / 9

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
3

                    

                    
                    
                    

                        
Atom Berat

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
An integrase strand transfer inhibitor used to treat HIV-1 infection as part of combination antiretroviral therapy. It prevents the virus from inserting its genetic material into human cells. It is typically formulated as a fixed-dose combination tablet taken once daily.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Bictegravir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3989866.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 90311989.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.